报告主题：Electrogenerated chemiluminescence: from materials to sensing applications

报 告 人：李海东 博士

报告时间：5月9日（周二）9:00

报告地点：理学院报告厅

报告主要内容：

Electrogenerated chemiluminescence (ECL) involves the energetic electron transfer reactions of electroactive molecules at the electrode with the generation of excited state, which then relax to the ground state and emit light. These ECL reactions can be divided into two main pathways: the annihilation and sacrificial co-reactant reactions. The latter has found a lot of applications in analytical chemistry. In this report, ECL studies toward three complementary directions are presented, ranging from the molecular to macroscopic scale: the research of new ECL luminophores, the study of stimuli-responsive hydrogel films, and the development of new ECL assays.

Firstly, two different types of organic dyes were selected for ECL investigations. These organic dyes exhibit interesting electrochemical and ECL properties. Spirofluorene dyes show strong ECL emission, and thus its fluorescence organic nanoparticles (FONs) prepared in water were used as ECL nano-emitters. Cationic helicenes dyes exhibit interesting electrochemical, photoluminescence and ECL properties. An ECL “map” was created for a fully overview of the energy proficiency in the ECL generation on helicene dyes. Secondly, the preparation of thermo-responsive poly (N-isopropylacrylamide) (pNIPAM) hydrogel films covalently incorporating Ru(bpy)₃²⁺ redox centers were achieved on glassy carbon electrode (GCE) or carbon fiber by electrochemically induced free radical polymerization. ECL studies on the modified GCEs have provided the main factor (the average distance of Ru(bpy)₃²⁺ sites) that governs the ECL process, leading to deciphering the enhanced ECL in the films. The deposition of the films on carbon fiber by bipolar electrochemistry (BPE) has opened new route to for the development of smart hybrid micro objects. Finally, analytical application is one of the most important features of ECL. Three different ECL assays were developed using the phenylboronic acid modified amine based co-reactants, gold coated optical fiber bundle and a mixed Ir(ppy)₃ and Ru(bpy)₃²⁺ system, respectively.  

报告人简介：

李海东博士毕业于法国波尔多大学分子研究所。曾在厦门大学及美国德克萨斯大学奥斯丁分校作博士后研究员，并在英国医学研究会剑桥线粒体研究所及香港大学从事研究工作。目前在新加坡科研局生物工程与纳米技术研究所（A*STAR-IBN）任职Principal Research Scientist，主要从事分子诊断，生物传感器及纳米技术的研究。

                                                                                                            理学院

2017年5月4日